A mimotope peptide-based vaccine against Schistosoma mansoni : synthesis and characterization
نویسندگان
چکیده
منابع مشابه
Synthesis and characterization of a protective peptide-based vaccine against Schistosoma mansoni.
Two synthetic peptides, corresponding to the N-terminal sequence of the 45-kDa subunit of the protective 9B antigen of Schistosoma mansoni and differing in only one amino acid residue, were synthesized. These peptides were recognized by the protective monoclonal antibody 152-66-9B, as well as by sera of mice and humans infected with schistosomiasis. The peptides were coupled to a protein carrie...
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The development of multivalent vaccines consisting of several antigens is a novel approach to creating broad-range protection against different parasite strains and parasite life cycle stages. We have previously confirmed that the schistosome Sm21.7 and SmFimbrin (SmFim) proteins could induce protection in mice. Therefore, this study aimed to construct the multivalent DNA vaccine Sm21.7-SmFim/p...
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ژورنال
عنوان ژورنال: Immunology
سال: 2000
ISSN: 0019-2805
DOI: 10.1046/j.1365-2567.2000.00139.x